Application of Pedestrian Upstream Detection Strategy in a Mixed Flow Traffic Circumstance

Walking is an environment-friendly trip mode and can help ease the congestion caused by automobiles. Proper design of pedestrian facilities that promotes efficiency and safety can encourage more people to choose walking. Upstream detection (UD) strategy is proposed by previous studies to reduce pedestrian waiting time at mid-block crosswalk (MBC). This paper applied UD strategy to MBC under mixed traffic circumstance where the crosswalk serves both pedestrians and non-motor users. Traffic data was collected from an MBC in the city of Nanjing, China. Simulation models were developed by using the VISSIM software and its add-on module Vehicle Actuated Programming (VAP). The models were categorised by the volume and composition of pedestrians and non-motor users. Models were simulated according to different experimental schemes to explore the effectiveness of the UD strategy under mixed traffic circumstance. T-test and analysis of variance (ANOVA) were used to interpret the simulation results. The main conclusions of this paper are that the UD strategy is still effective at the MBC with a mixed traffic circumstance despite the proportion of non-motor users. However, as the proportion of non-motor users becomes higher, the average delay of pedestrians and non-motor users will increase compared to pure pedestrian flow

Individual differences in emoji comprehension: Gender, age, and culture

Emoji are an important substitute for non-verbal cues (such as facial expressions) in online written communication. So far, however, little is known about individual differences regarding how they are perceived. In the current study, we examined the influence of gender, age, and culture on emoji comprehension. Specifically, a sample of 523 participants across the UK and China completed an emoji classification task. In this task, they were presented with a series of emoji, each representing one of six facial emotional expressions, across four commonly used platforms (Apple, Android, WeChat, and Windows). Their task was to choose from one of six labels (happy, sad, angry, surprised, fearful, disgusted) which emotion was represented by each emoji. Results showed that all factors (age, gender, and culture) had a significant impact on how emojis were classified by participants. This has important implications when considering emoji use, for example, conversation with partners from different cultures

Nanopeptide C-I20 as a novel feed additive effectively alleviates detrimental impacts of soybean meal on mandarin fish by improving the intestinal mucosal barrier

Antibacterial peptide has been widely developed in cultivation industry as feed additives. However, its functions in reducing the detrimental impacts of soybean meal (SM) remain unknown. In this study, we prepared nano antibacterial peptide CMCS-gcIFN-20H (C-I20) with excellent sustained-release and anti-enzymolysis, and fed mandarin fish (Siniperca chuatsi) with a SM diet supplemented with different levels of C-I20 (320, 160, 80, 40, 0 mg/Kg) for 10 weeks. 160 mg/Kg C-I20 treatment significantly improved the final body weight, weight gain rate and crude protein content of mandarin fish and reduced feed conversion ratio. 160 mg/Kg C-I20-fed fish maintained appropriate goblet cells number and mucin thickness, as well as improved villus length, intestinal cross-sectional area. Based on these advantageous physiological changes, 160 mg/Kg C-I20 treatment effectively reduced multi-type tissue (liver, trunk kidney, head kidney and spleen) injury. The addition of C-I20 did not change the muscle composition and muscle amino acids composition. Interestingly, dietary 160 mg/Kg C-I20 supplementation prevented the reduction in myofiber diameter and change in muscle texture, and effectively increased polyunsaturated fatty acids (especially DHA + EPA) in muscle. In conclusion, dietary C-I20 in a reasonable concentration supplementation effectively alleviates the negative effects of SM by improving the intestinal mucosal barrier. The application of nanopeptide C-I20 is a prospectively novel strategy for promoting aquaculture development

Analysis of the clinicopathological characteristics and prognosis of triple-positive breast cancer and HER2-positive breast cancer—A retrospective study

BackgroundAdjuvant chemotherapy and targeted therapy have become standard postoperative therapeutic modalities for human epidermal growth factor receptor 2 (HER2)-positive breast cancer(HER2-positive,HR-negative), including triple-positive breast cancer(HER2-positive,HR-positive). However, these two types of breast cancer differ in terms of pathogenesis. This article analyzes these two types of breast cancer by comparing their prognoses.MethodsThe clinicopathological characteristics of 135 patients, including 60 patients with triple-positive breast cancer and 75 patients with HER2-positive breast cancer, were analyzed to compare the disease-free survival (DFS) and overall survival (OS) of the two groups over a 5-year period. A multifactorial Cox risk model was constructed by grouping age, menstrual status, maximum tumor diameter, number of lymph node metastases, pathological staging, and Ki-67 staining results. All statistical data were analyzed in detail using SPSS25.0 statistical software.ResultsThe 5-year OS rates of patients with breast cancer in the triple-positive and HER2-positive groups were 96.7% and 82.7%, respectively, and the 5-year DFS rates were 90% and 73.3%, respectively. The Cox results revealed that molecular staging was an independent factor affecting recurrent metastasis and survival of breast cancer patients (hazard ratio [HR] =2.199, 95% confidence interval [CI], 1.296-8.266; HR = 9.994, 95% CI, 2.019-49.465).ConclusionThe 5-year DFS and OS rates were significantly better in the triple-positive group than in the HER2-positive group. Subgroups received different prognosis for different chemotherapy regimens. Breast cancer patients should be treated according to the risk of recurrence with symptomatic treatment and precise regulation